Regulation of Vascular Tone and Pulse Wave Velocity in Human Muscular Conduit Arteries
Why the study?
How do different vasodilator drugs affect radial artery diameter and pulse wave velocity in human muscular conduit arteries?
Population
Human subjects (specific demographics and sample size not provided in abstract)
Comparison
Intrabrachial arterial infusion of vasodilator… vs Comparison among the different vasodilator drugs
Design
Other
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for NO donor effects on wave reflection; clinical outcome trials needed before practice change.
Structured PICO
How do different vasodilator drugs affect radial artery diameter and pulse wave velocity in human muscular conduit arteries?
P
Population
Human subjects (specific demographics and sample size not provided in abstract)
I
Intervention
Intrabrachial arterial infusion of vasodilator drugs (nitroglycerine, nitroprusside, brain natriuretic peptide, phentolamine, verapamil, and hydralazine)
C
Comparator
Comparison among the different vasodilator drugs
O
Outcome
Radial artery diameter, forearm blood flow, and pulse wave velocitysurrogate
Nitric oxide donors specifically dilate large muscular conduit arteries and decrease pulse wave velocity, suggesting a pathway to manipulate pressure wave reflection and systolic blood pressure.
Cite This Study
Fok et al. (2012) studied this question.