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May 1, 1985Journal of Cardiovascular Pharmacology

Biological Properties of the Angiotensin-Converting Enzyme Inhibitor Cilazapril

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Why the study?

Does cilazapril demonstrate greater potency and longer duration of action compared to captopril and enalapril in preclinical models?

Population

In vitro systems, isolated guinea pig ileum, rats, spontaneously hypertensive rats, and two-kidney renal…

Comparison

Cilazapril (and its active diacid) vs Captopril and enalapril (and its active diacid)

Design

Preclinical

Authors

INIan L. NatoffRoche (United Kingdom)JNJohn NixonUniversity of YorkRFRobert J. FrancisRoche (Switzerland)

Discussion

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Implication

Animal findings should not alter ACE inhibitor prescribing; leaves open translation of potency to human outcomes.

Structured PICO

Does cilazapril demonstrate greater potency and longer duration of action compared to captopril and enalapril in preclinical models?

P
Population
In vitro systems, isolated guinea pig ileum, rats, spontaneously hypertensive rats (SHR), and two-kidney renal hypertensive rats
I
Intervention
Cilazapril (and its active diacid)
C
Comparator
Captopril and enalapril (and its active diacid)
O
Outcome
ACE inhibition and blood pressure reductionsurrogate

Cilazapril is a highly potent, long-acting ACE inhibitor with superior preclinical pharmacological properties compared to captopril and enalapril.

Cite This Study

Natoff et al. (1985) studied this question.

synapsesocial.com/papers/6a8bef7bdbcda37421e9501fhttps://doi.org/10.1097/00005344-198505000-00025
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antihypertensive Effects and Pharmacokinetics of Single and Consecutive Doses of Cilazapril in Hypertensive Patients with Normal and Impaired Renal Function1988 · 29 citations
  2. 2Antihypertensive Effects and Pharmacokinetics of Single and Consecutive Doses of Cilazapril in Hypertensive Patients with Normal and Impaired Renal Function1988 · 2 citations
  3. 3Antihypertensive effects and pharmacokinetics of single and consecutive doses of cilazapril in hypertensive patients with normal or impaired renal function.1989 · 7 citations
  4. 4Antihypertensive and renal effects of cilazapril and their reversal by angiotensin in renovascular hypertensive rats1988 · 12 citations
  5. 5Pharmacokinetics and haemodynamic effects of the angiotensin converting enzyme inhibitor cilazapril in hypertensive patients with normal and impaired renal function1996 · 2 citations