Why the study?
Does moexipril prevent glomerular injury in rats with streptozotocin-induced diabetes when started at different phases of the disease?
Population
Rats with streptozotocin-induced diabetes treated with insulin
Comparison
Moexipril for 8 weeks, started either early or… vs Insulin alone (no ACE inhibitor)
Design
Preclinical
Follow-up
8 weeks
Authors
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Timing of ACE inhibition may be critical in diabetic kidney disease; leaves open translation to human prevention strategies.
Does moexipril prevent glomerular injury in rats with streptozotocin-induced diabetes when started at different phases of the disease?
Early initiation of ACE inhibitor therapy in diabetic rats completely prevents glomerular injury, highlighting the importance of treatment timing.
Perico et al. (1994) studied this question.
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