Population
Chronically instrumented conscious dogs
Comparison
Atrial natriuretic peptide (ANP) 3 micrograms/kg vs Before ANP pretreatment (baseline state)
Design
Preclinical
Authors
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Hypothesis-generating for ANP in coronary vasoregulation; leaves open translation to human disease.
In a canine model, ANP attenuated the augmented reactive hyperemia seen with flow-limiting coronary stenosis, suggesting dilation of the intramural vasculature.
Chu et al. (1989) studied this question.
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