Why the study?
Does intravenous atrial natriuretic peptide reduce blood pressure and blood volume in uremic patients on maintenance dialysis compared to healthy subjects?
Population
11 uremic patients on chronic maintenance dialysis and 11 healthy subjects (n=22)
Comparison
Intravenous bolus injection of atrial… vs Baseline values and healthy subjects
Design
Other
Follow-up
30 minutes
Authors
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ANP lowers BP similarly in dialysis patients and controls; leaves open therapeutic role pending randomized trials.
Does intravenous atrial natriuretic peptide reduce blood pressure and blood volume in uremic patients on maintenance dialysis compared to healthy subjects?
A pharmacological dose of atrial natriuretic peptide reduces blood pressure in uremic patients on maintenance dialysis to the same extent as in healthy subjects, independent of fluid shifts.
Jespersen et al. (1990) studied this question.
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