What does this research mean for the field?

Four weeks of cerebellar transcranial direct current stimulation (tDCS) significantly improves cognitive and balance dysfunction in patients with stroke, with delayed positive effects on lower limb motor function. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the efficacy of cerebellar transcranial direct current stimulation (tDCS) on cognitive and motor dysfunctions in patients with cerebral hemisphere stroke.

August 24, 2026Scientific ReportsOpen Access

Effects of cerebellar transcranial direct current stimulation on cognitive and motor impairments in patients with stroke a randomized clinical trial

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Authors

龚龚秋纹Army Medical University DZDongyun ZhangArmy Medical University ZFZhou FengArmy Medical University

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Implication

Randomized trial demonstrates enhanced cognitive and balance recovery with cerebellar tDCS in stroke patients, highlighting a targeted neuromodulatory rehabilitation approach.

Key Points

To evaluate the efficacy of cerebellar transcranial direct current stimulation (tDCS) on cognitive and motor dysfunctions in patients with cerebral hemisphere stroke.
Randomized, single-blind, sham-controlled prospective trial involving 74 patients with stroke assigned 1:1 to active tDCS (n = 37) or sham tDCS (n = 37).
Participants received cerebellar active or sham tDCS for 20 minutes daily, 5 days per week for 4 weeks alongside standardized rehabilitation therapy and cognitive training.
At 4 weeks, active tDCS resulted in significantly greater MoCA score improvements (mean difference, 1.73 [95% CI, 0.36–3.10]; P = 0.004) and a higher response rate (78.4% vs 54.1%; OR, 3.08 [95% CI, 1.12–8.50]; P = 0.015).
Active tDCS significantly increased Berg Balance Scale scores compared to sham (mean difference, 5.43 [95% CI, 0.23–10.64]; P = 0.037; response rate: 78.4% vs 48.6%; OR, 3.90 [95% CI, 1.37–11.09]; P = 0.011).
Lower extremity motor scores (FMA-LE) did not differ significantly at 4 weeks (mean difference, 0.41 [95% CI, -2.12 to 2.93]; P = 0.517), but significantly favored active tDCS at 12-week follow-up (mean difference, 3.41 [95% CI, 0.04–6.77]; P = 0.023).

Cite This Study

龚秋纹 et al. (2026) studied this question.

synapsesocial.com/papers/6a8c0070bca056c88e6df2ef https://doi.org/10.1038/s41598-026-65174-4

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Implication

Randomized trial demonstrates enhanced cognitive and balance recovery with cerebellar tDCS in stroke patients, highlighting a targeted neuromodulatory rehabilitation approach.

Effects of cerebellar transcranial direct current stimulation on cognitive and motor impairments in patients with stroke a randomized clinical trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Effects of cerebellar transcranial direct current stimulation on cognitive and motor impairments in patients with stroke a randomized clinical trial

Discussion

Member takes

Implication

Key Points

Cite This Study

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