Why the study?
How do cardiovascular responses to norepinephrine, angiotensin II, and calcium antagonists differ between patients with essential hypertension and normotensive individuals?
How do cardiovascular responses to norepinephrine, angiotensin II, and calcium antagonists differ between patients with essential hypertension and normotensive individuals?
Patients with essential hypertension show exaggerated blood pressure responses to rest and norepinephrine, which are attenuated by calcium antagonists, suggesting enhanced NE-dependent calcium influx in arterial smooth muscle.
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Hypertensives show NE-specific BP responses attenuated by calcium antagonists; hypothesis-generating for vascular mechanisms but should not change practice.
Aoki et al. (1985) studied this question.
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