Key result
Genetic removal of CNNM2 and NT5C2 in zebrafish larvae resulted in higher blood flow, increased arterial pulse, and elevated linear velocity, confirming their role in hypertension.
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This commentary highlights the utility of the zebrafish model in validating CNNM2 and NT5C2 as causal genes for hypertension at the 10q24.32 locus.
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Sorriento et al. (2020) conducted an editorial in Hypertension. CNNM2 and NT5C2 knock-out was evaluated. Genetic removal of CNNM2 and NT5C2 in zebrafish larvae resulted in higher blood flow, increased arterial pulse, and elevated linear velocity, confirming their role in hypertension.
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