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July 1, 1999HypertensionOpen Access

Evidence for Linkage Between Essential Hypertension and a Putative Locus on Human Chromosome 17

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Population

Humans with essential hypertension

Design

Other

Authors

JBJader BaimaBoston UniversityMNMichael NicolaouUniversity of GlasgowFSFaina SchwartzBoston University

Discussion

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Implication

Does not alter hypertension management; leaves open whether 17q variants warrant clinical translation.

Structured PICO

P
Population
Humans with essential hypertension
O
Outcome
Linkage to human chromosome 17qsurrogate

This study provides genetic evidence linking essential hypertension to a specific locus on human chromosome 17, supporting a genetic basis for blood pressure regulation.

Cite This Study

Baima et al. (1999) studied this question.

synapsesocial.com/papers/6a845a2c7b4d6f59a47c07eahttps://doi.org/10.1161/01.hyp.34.1.4

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Genetic Susceptibility for Human Familial Essential Hypertension in a Region of Homology with Blood Pressure Linkage on Rat Chromosome 101997 · 178 citations
  2. 2Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10.1995 · 73 citations
  3. 3Mapping of quantitative trait loci for blood pressure and cardiac mass in the rat by genome scanning of recombinant inbred strains.1995 · 167 citations
  4. 4Evidence for Association and Genetic Linkage of the Angiotensin-Converting Enzyme Locus With Hypertension and Blood Pressure in Men but Not Women in the Framingham Heart Study1998 · 555 citations
  5. 5Angiotensin Converting Enzyme Gene Polymorphism Is Not Related to Essential Hypertension in a Greek Population1996 · 53 citations