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March 1, 1993AJP Heart and Circulatory Physiology

Compensatory downregulation of myocardial Ca channel in SR from dogs with heart failure

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Authors

CCC. R. CoryOntario Veterinary College LML. Jill McCutcheonSan Antonio College MOM. O'GradyAdelaide Institute for Sleep Health

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Implication

Defective SR Ca handling may underlie contractile failure in canine CHF models; leaves open translation to human therapeutic targets.

Key Points

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Cite This Study

Cory et al. (1993) studied this question.

synapsesocial.com/papers/6a8c0eec2ff0ab4f91e963ee https://doi.org/10.1152/ajpheart.1993.264.3.h926

Topics

Heart failure HFrEF treatment

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abnormal Ca2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure1999 · 67 citations
2Abnormal Ca 2+ Release, but Normal Ryanodine Receptors, in Canine and Human Heart Failure2002 · 248 citations
3Cellular and molecular determinants of altered Ca2+handling in the failing rabbit heart: primary defects in SR Ca2+uptake and release mechanisms2006 · 61 citations
4The relationship between arrhythmogenesis and impaired contractility in heart failure: role of altered ryanodine receptor function2011 · 122 citations
5Decreased Sarcoplasmic Reticulum Calcium Content Is Responsible for Defective Excitation-Contraction Coupling in Canine Heart Failure2001 · 271 citations