Population
Various vertebrate cell lines including human fibroblasts, monkey, steer, sheep, dog, cat, rat, mouse…
Comparison
Human foamy virus vectors encoding neomycin… vs Murine leukemia virus (MLV) vectors (LAPSN)
Design
Preclinical
Authors
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HFV vectors may support gene delivery to nondividing cells; this Level 5 finding leaves open in vivo safety and efficacy.
HFV vectors demonstrate broad tropism, resistance to human serum, and the ability to transduce non-dividing cells more efficiently than MLV vectors, making them promising vehicles for gene transfer.
Russell et al. (1996) studied this question.
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