Key result
Current smoking was not an independent predictor of adverse outcomes after acute coronary syndrome when fully adjusted for baseline characteristics, debunking the smoker's paradox.
Why the study?
Does current smoking improve outcomes in patients with acute coronary syndrome?
Cohort (n=2,727)
No
Does current smoking improve outcomes in patients with acute coronary syndrome?
The 'smoker's paradox' in acute coronary syndrome is not a true protective effect, but rather an artifact of smokers presenting at a younger age with fewer baseline comorbidities.
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No outcome benefit from smoking in ACS; supports the paradox as confounding artifact in observational data.
Moreira et al. (2018) conducted a cohort in Acute coronary syndrome (n=2,727). Current smoking vs. Never-smokers was evaluated on In-hospital mortality and a composite of all-cause mortality, rehospitalization for cardiovascular causes, angiography, percutaneous coronary intervention and coronary artery bypass grafting. Current smoking was not an independent predictor of adverse outcomes after acute coronary syndrome when fully adjusted for baseline characteristics, debunking the smoker's paradox.
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