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Stage-specific LYT1 mRNA processing in T. cruzi is hypothesis-generating for Chagas interventions; leaves open isoform-specific functions and therapeutic targeting.
As a result of alternative trans splicing, three distinct LYT1 mRNAs are produced in Trypanosoma cruzi, two encoding the full-length LYT1 protein and the third encoding a truncated LYT1 protein lacking a possible signal sequence. Analysis of the three mRNAs in different developmental forms of the parasite revealed that the alternative processing events were regulated differently during the parasite life cycle.
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Manning‐Cela et al. (2002) studied this question.
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