Key result
Admission serum H-FABP outperforms myoglobin with ~91% sensitivity for early myocardial infarction.
Why the study?
The diagnostic performance of the sandwich ELISA MARKIT-M for measuring serum heart fatty acid-binding protein (H-FABP) in suspected myocardial infarction was evaluated.
Does serum H-FABP measurement using sandwich ELISA MARKIT-M improve diagnostic sensitivity compared to myoglobin in patients with suspected myocardial infarction?
Cross-Sectional (n=71)
Does serum H-FABP measurement using sandwich ELISA MARKIT-M improve diagnostic sensitivity compared to myoglobin in patients with suspected myocardial infarction?
Serum H-FABP measured by sandwich ELISA offers significantly higher sensitivity than myoglobin for the early detection of suspected myocardial infarction.
Background: We evaluated the sandwich enzyme-linked immunosorbent assay (ELISA) MARKIT ® -M for the determination of heart fatty-acid-binding protein (H-FABP). Results and Conclusions: The between-run coefficient of variation of this assay was <3·9 and it showed good correlation with a previously established ELISA method. The upper reference limit in 30 healthy individuals was 6·1 μg/L. Admission serum H-FABP was evaluated against myoglobin in 41 patients with suspected myocardial infarction (onset of symptoms ≤ 5 h). H-FABP showed the same diagnostic efficiency as myoglobin [area (standard error) under the receiver operating characteristic curve: 0·798 (0·079) for H-FABP, 0·771 (0·085) for myoglobin, P = 0·55]. However, using the upper reference limit as decision cut-off, the sensitivity for H-FABP [91%; 95% confidence interval (CI): 76-98%] was significantly ( P = 0·019) higher than that of myoglobin (65%; 95% CI: 47-80%).
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Pagani et al. (2002) conducted a cross-sectional in Suspected myocardial infarction (n=71). Serum heart fatty acid-binding protein (H-FABP) measurement via sandwich ELISA vs. Myoglobin was evaluated on Diagnostic sensitivity using the upper reference limit as decision cut-off (p=0.019). Admission serum H-FABP showed significantly higher sensitivity (91%) compared to myoglobin (65%; P=0.019) for diagnosing suspected myocardial infarction within 5 hours of symptom onset.
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