Key result
H-FABP assays detect only ~58% of acute MIs, demonstrating lower sensitivity than initial troponin.
Why the study?
Previous studies have shown inconsistent correlation of heart-type fatty acid-binding protein with standard cardiac biomarkers for early diagnosis of myocardial infarction.
Does H-FABP measurement improve the early diagnosis of acute myocardial infarction compared to standard troponin assays in patients admitted with acute coronary syndrome?
Comparison
Qualitative and quantitative H-FABP assays vs initial troponin assay
Design
Observational study
Authors
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May support adjunctive H-FABP testing in ACS; leaves open incremental value over troponin in small observational data.
Observational (n=50)
Does H-FABP measurement improve the early diagnosis of acute myocardial infarction compared to standard troponin assays in patients admitted with acute coronary syndrome?
Absolute Event Rate: 58% vs 88%
p-value: p=0.001
H-FABP assays do not provide earlier detection or increased sensitivity compared to standard troponin assays for diagnosing acute myocardial infarction, limiting their diagnostic utility.
Rosman et al. (2009) conducted an observational in Acute coronary syndrome (n=50). Heart-type fatty acid-binding protein (H-FABP) assay vs. Troponin assay was evaluated on Positive assay in patients with acute MI (p=0.001). Qualitative and quantitative H-FABP assays were positive in 58% and 38% of acute MI patients, respectively, compared to 88% for the initial troponin assay (P=0.001).
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