Key result
Isoflurane abolished the ability of platelets to enhance neutrophil-induced coronary endothelial dysfunction, superoxide production, and vascular adherence in dog coronary artery segments.
Why the study?
Does isoflurane prevent platelets from enhancing neutrophil-induced coronary endothelial dysfunction in a canine model?
Does isoflurane prevent platelets from enhancing neutrophil-induced coronary endothelial dysfunction in a canine model?
Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction, providing evidence for its cardioprotective effects via inhibitory actions on inflammatory cells.
Authors
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Should not change anesthetic selection in coronary disease; leaves open translation of isoflurane's anti-inflammatory effects to clinical cardioprotection.
Hu et al. (2005) studied healthy dogs (n=25). Isoflurane vs. Absence of isoflurane was evaluated on Concentration-vasorelaxation response to acetylcholine, superoxide production, and neutrophil adherence. Isoflurane abolished the ability of platelets to enhance neutrophil-induced coronary endothelial dysfunction, superoxide production, and vascular adherence in dog coronary artery segments.
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