Why the study?
Does pretreatment of neutrophils with volatile anesthetics prevent neutrophil-induced cardiac dysfunction in isolated rat hearts?
Population
60 buffer-perfused and paced isolated rat hearts
Comparison
Pretreatment of neutrophils with 1.0 MAC… vs Activated neutrophils without volatile…
Design
Preclinical
Follow-up
30 min of recovery
Authors
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May attenuate neutrophil-induced myocardial dysfunction in rat hearts; hypothesis-generating for clinical cardioprotection.
Does pretreatment of neutrophils with volatile anesthetics prevent neutrophil-induced cardiac dysfunction in isolated rat hearts?
Volatile anesthetics like isoflurane and sevoflurane inhibit neutrophil activation and adherence, preventing neutrophil-induced cardiac dysfunction in an isolated rat heart model.
Hu et al. (2003) studied this question.
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