April 1, 2002Anesthesia & Analgesia

Isoflurane Inhibits Neutrophil-Endothelium Interactions in the Coronary Circulation: Lack of a Role for Adenosine Triphosphate-Sensitive Potassium Channels

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Why the study?

Does isoflurane inhibit neutrophil-endothelium interactions in the coronary circulation?

Population

Polymorphonuclear neutrophils and coronary artery segments obtained from 35 healthy dogs

Comparison

Isoflurane with and without glibenclamide vs Absence of isoflurane

Design

Preclinical

Authors

GHGuochang HuIllinois College JVJakob Vinten‐JohansenEmory University MSM. Ramez SalemAdvocate Illinois Masonic Medical Center

Discussion

Member takes

Implication

Hypothesis-generating for isoflurane-mediated coronary endothelial protection in animal models; leaves open translation to clinical anesthesia practice.

Structured PICO

Does isoflurane inhibit neutrophil-endothelium interactions in the coronary circulation?

Population

Polymorphonuclear neutrophils and coronary artery segments obtained from 35 healthy dogs

Intervention

Isoflurane (1 and 2 minimum alveolar anesthetic concentration) with and without glibenclamide (10 microM)

Comparator

Absence of isoflurane

Outcome

Superoxide production by neutrophils, adherence of PAF-activated neutrophils to endothelium, and vasorelaxation responses to acetylcholine and sodium nitroprussidesurrogate

Isoflurane inhibits neutrophil-endothelium interactions and neutrophil-mediated coronary endothelial dysfunction in vitro via a pathway independent of ATP-sensitive potassium channels.

Cite This Study

Hu et al. (2002) studied this question.

synapsesocial.com/papers/6a840df125efb1e71e83d6bb https://doi.org/10.1097/00000539-200204000-00013

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Implication

Hypothesis-generating for isoflurane-mediated coronary endothelial protection in animal models; leaves open translation to clinical anesthesia practice.