Key result
Pretreatment with isoflurane or sevoflurane abolished the marked reductions (>50%) in left ventricular developed pressure caused by platelet-activating factor-stimulated neutrophils in isolated rat hearts.
Why the study?
Does pretreatment with isoflurane or sevoflurane prevent neutrophil-induced contractile dysfunction in isolated rat hearts?
Population
Buffer-perfused and paced isolated rat hearts and isolated rat aortic segments
Comparison
Pretreatment with 1.0 minimum alveolar… vs No pretreatment (control)
Design
Preclinical
Follow-up
30 min of recovery
Authors
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May protect isolated rat hearts from neutrophil injury; leaves open clinical translation of volatile anesthetic preconditioning.
Does pretreatment with isoflurane or sevoflurane prevent neutrophil-induced contractile dysfunction in isolated rat hearts?
Isoflurane and sevoflurane precondition the heart against neutrophil-induced contractile dysfunction, likely by inhibiting neutrophil adherence and increasing resistance to oxidant injury.
Hu et al. (2004) studied Neutrophil-induced contractile dysfunction. Isoflurane or sevoflurane vs. No pretreatment was evaluated on Left ventricular developed pressure. Pretreatment with isoflurane or sevoflurane abolished the marked reductions (>50%) in left ventricular developed pressure caused by platelet-activating factor-stimulated neutrophils in isolated rat hearts.
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