Population
Isolated guinea pig hearts perfused with Krebs-Ringer's solution at 55 mm Hg
Comparison
Sevoflurane preconditioning or Ischemic… vs No treatment before ischemia, or…
Design
Preclinical, randomly assigned to one of seven groups
Follow-up
75 min of reperfusion
Authors
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Supports mechanistic studies of anesthetic preconditioning; leaves open clinical translation pending human data.
Sevoflurane preconditioning mimics ischemic preconditioning by improving postischemic contractility, coronary flow, and nitric oxide release via K(ATP) channel activation in isolated hearts.
Novalija et al. (1999) studied this question.
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