Why the study?
Does dual brief exposure to sevoflurane improve anesthetic preconditioning and reduce infarct size compared to a single longer exposure in Langendorff-prepared guinea pig hearts?
Population
Langendorff-prepared guinea pig hearts (n=32)
Comparison
Two brief exposures to sevoflurane followed by… vs Single longer exposure to sevoflurane or control
Design
Preclinical
Follow-up
120 min of reperfusion
Authors
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May enhance preconditioning with repeated sevoflurane in isolated hearts; hypothesis-generating and requires clinical validation.
Does dual brief exposure to sevoflurane improve anesthetic preconditioning and reduce infarct size compared to a single longer exposure in Langendorff-prepared guinea pig hearts?
Repeated brief exposures to sevoflurane provide better anesthetic preconditioning and reduction in infarct size than a single longer exposure in a guinea pig heart model.
Riess et al. (2004) studied this question.
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