Key result
Sevoflurane after ischemic late preconditioning cuts infarct size ~48% versus either alone via KATP channel opening.
Why the study?
Does sevoflurane combined with ischemic late preconditioning reduce infarct size in a rabbit model of ischemia/reperfusion?
Population
73 rabbits instrumented with a coronary artery occluder, subjected to 30 min of coronary artery occlusion…
Comparison
Sevoflurane inhalation combined with ischemic… vs No preconditioning, ischemic late…
Design
Preclinical
Follow-up
120 min of reperfusion
Authors
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May enhance experimental cardioprotection; hypothesis-generating and should not yet change practice.
Does sevoflurane combined with ischemic late preconditioning reduce infarct size in a rabbit model of ischemia/reperfusion?
Absolute Event Rate: 14% vs 45%
p-value: p=0.003 vs. LPC; 0.032 vs. SEVO
Sevoflurane provides additive cardioprotection to ischemic late preconditioning in a rabbit model, mediated by KATP channel opening.
Müllenheim et al. (2003) studied Myocardial ischemia/reperfusion injury (n=73). Sevoflurane after ischemic late preconditioning (LPC+SEVO) vs. Control (no preconditioning), LPC alone, or SEVO alone was evaluated on Infarct size of the area at risk (p=0.003 vs. LPC; 0.032 vs. SEVO). Sevoflurane administration after ischemic late preconditioning further reduced infarct size to 14% compared to 27% with either intervention alone, an effect mediated by opening KATP channels.