Why the study?
Does pretreatment with volatile anesthetics prevent neutrophil-induced contractile dysfunction in isolated rat hearts via adenosine receptors?
Population
Buffer-perfused and paced isolated rat hearts and polymorphonuclear neutrophils
Comparison
Pretreatment of neutrophils or hearts with 1.0… vs Control conditions (no anesthetic pretreatment)
Design
Preclinical
Follow-up
30 min of recovery
Authors
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Animal data extend mechanistic insight into neutrophil adenosine receptors; leaves open clinical translation for volatile anesthetic cardioprotection.
Does pretreatment with volatile anesthetics prevent neutrophil-induced contractile dysfunction in isolated rat hearts via adenosine receptors?
Volatile anesthetics precondition against neutrophil-induced contractile dysfunction via activation of adenosine receptors in neutrophils, but not in the heart.
Hu et al. (2005) studied this question.
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