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November 18, 2005AnesthesiologyOpen Access

Effects of Nitrous Oxide on the Rat Heart In Vivo

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Why the study?

Does nitrous oxide precondition the heart against ischemia-reperfusion injury in a rat model?

Population

Anesthetized rats subjected to 25 min of coronary artery occlusion followed by 120 min of reperfusion

Comparison

Nitrous oxide, isoflurane, or isoflurane-nitrous… vs Control animals remaining untreated for 45 min…

Design

Preclinical

Follow-up

120 min of reperfusion

Authors

NWNina C. WeberAmsterdam NeuroscienceOTOctavian TomaUniversity of East AngliaSASaqib Ejaz AwanThe University of Western Australia

Discussion

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Implication

Nitrous oxide lacks preconditioning unlike isoflurane; hypothesis-generating for anesthetic-specific effects and requires human confirmation.

Structured PICO

Does nitrous oxide precondition the heart against ischemia-reperfusion injury in a rat model?

P
Population
Anesthetized rats subjected to 25 min of coronary artery occlusion followed by 120 min of reperfusion
I
Intervention
Nitrous oxide (60%), isoflurane (1.4%), or isoflurane-nitrous oxide (1.4%/60% or 0.6%/60%) administered during three 5-min periods before index ischemia
C
Comparator
Control animals remaining untreated for 45 min before index ischemia
O
Outcome
Infarct size as a percentage of the area at risksurrogate

Nitrous oxide is the first inhalational anesthetic shown to lack a preconditioning effect on the heart, though it does not interfere with isoflurane-induced preconditioning.

Cite This Study

Weber et al. (2005) studied this question.

synapsesocial.com/papers/6a8902a7ab71709247a2abc6https://doi.org/10.1097/00000542-200512000-00011
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Protein Kinase C Translocation and Src Protein Tyrosine Kinase Activation Mediate Isoflurane-induced Preconditioning In Vivo 2004 · 85 citations
  2. 2Role of Tyrosine Kinase in Desflurane-induced Preconditioning2004 · 11 citations
  3. 3Desflurane Preconditioning Induces Time-dependent Activation of Protein Kinase C Epsilon and Extracellular Signal-regulated Kinase 1 and 2 in the Rat Heart In Vivo 2004 · 89 citations
  4. 4Colchicine Inhibits Isoflurane-induced Preconditioning 1999 · 22 citations
  5. 5Protein Tyrosine Kinase-Dependent Modulation of Isoflurane Effects on Cardiac Sarcolemmal KATPChannel2002 · 27 citations