January 1, 1991Journal of Leukocyte Biology

Differentiation of Rat Bone Marrow Cells Into Macrophages Under the Influence of Mouse L929 Cell Supernatant

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Population

Human neutrophils (PMNs) and platelets in vitro

Design

Preclinical

Authors

CNChris NaumIndiana University – Purdue University Indianapolis SKSandra S. KaplanPenn Presbyterian Medical Center RBR. E. BasfordUniversity of Pittsburgh

Discussion

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Implication

Biphasic platelet effects on neutrophil superoxide may influence oxidative stress; hypothesis-generating for cardiovascular inflammation and requires in vivo confirmation.

Structured PICO

Population

Human neutrophils (PMNs) and platelets in vitro

Intervention

Varying platelet-to-PMN ratios (1:1 to 100:1), ATP concentrations (1 x 10(-6) to >6.4 x 10(-4) M), ADP concentrations, and incubation times

Outcome

Superoxide anion (O2-) productionsurrogate

Platelets exert a biphasic, concentration- and time-dependent modulatory effect on neutrophil superoxide production in vitro.

Cite This Study

Naum et al. (1991) studied this question.

synapsesocial.com/papers/6a7c1d2948312d37e47605cd https://doi.org/10.1002/jlb.49.1.83

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Implication

Biphasic platelet effects on neutrophil superoxide may influence oxidative stress; hypothesis-generating for cardiovascular inflammation and requires in vivo confirmation.

Differentiation of Rat Bone Marrow Cells Into Macrophages Under the Influence of Mouse L929 Cell Supernatant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Differentiation of Rat Bone Marrow Cells Into Macrophages Under the Influence of Mouse L929 Cell Supernatant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider