May 1, 1993AJP Heart and Circulatory Physiology

Polymorphonuclear leukocyte-derived O2-reactive species activate primed platelets in human whole blood

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Population

Human whole blood

Comparison

N-formyl-Met-Leu-Phe combined with priming… vs Arachidonic acid alone, collagen alone, or FMLP…

Design

Preclinical

Authors

DPDomenico PraticòTemple University LILuigi IulianoSapienza University of Rome CACristiano AlessandriPoliclinico Umberto I

Discussion

Member takes

Implication

Suggests oxidant-mediated platelet activation when primed; hypothesis-generating for human thrombosis mechanisms.

Structured PICO

Population

Human whole blood

Intervention

N-formyl-Met-Leu-Phe (FMLP) combined with priming concentrations of arachidonic acid or collagen

Comparator

Arachidonic acid alone, collagen alone, or FMLP alone

Outcome

Platelet aggregation and thromboxane A2 productionsurrogate

Platelets primed with minute amounts of arachidonic acid or collagen can be activated in human whole blood by oxygen-reactive species released by polymorphonuclear leukocytes.

Cite This Study

Praticò et al. (1993) studied this question.

synapsesocial.com/papers/6a7052ca26770c2b8de07693 https://doi.org/10.1152/ajpheart.1993.264.5.h1582

View Full Paper

Ask AI

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Polymorphonuclear leukocyte-derived O2-reactive species activate primed platelets in human whole blood

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Polymorphonuclear leukocyte-derived O2-reactive species activate primed platelets in human whole blood

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider