Key result
Mediators released from polymorphonuclear leukocytes, such as free radicals, arachidonic acid metabolites, and nitric oxide, modulate the platelet aggregation response.
Population
In vitro studies of platelets and polymorphonuclear leukocytes (PMNLs)
Design
Review
Authors
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May inform future antithrombotic targets; leaves open in vivo relevance to clinical thrombosis.
This review highlights the complex in vitro interactions between polymorphonuclear leukocytes and platelets, mediated by various released factors that modulate platelet aggregation.
Dikshit et al. (1997) conducted a review in Platelet aggregation and polymorphonuclear leukocyte interaction. Mediators released from polymorphonuclear leukocytes was evaluated on Platelet aggregation response. Mediators released from polymorphonuclear leukocytes, such as free radicals, arachidonic acid metabolites, and nitric oxide, modulate the platelet aggregation response.
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