Key result
Atorvastatin, olmesartan, resveratrol, and their combination significantly reduced TGF-β1-induced α-smooth muscle actin expression in rabbit valvular interstitial cells (p<0.001).
Why the study?
Valvular interstitial cell differentiation into myofibroblasts plays an important role in pathological valve remodeling in rheumatic valvular disease.
Do atorvastatin, olmesartan, resveratrol, or their combination reduce TGF-β1-induced myofibroblast differentiation in rabbit valvular interstitial cells?
Do atorvastatin, olmesartan, resveratrol, or their combination reduce TGF-β1-induced myofibroblast differentiation in rabbit valvular interstitial cells?
Atorvastatin, olmesartan, resveratrol, and their combination significantly reduce TGF-β1-induced myofibroblast differentiation in an experimental rabbit heart valve model.
Answers are grounded in this paper and cite their sources.
No immediate clinical implications for valvular disease; leaves open antifibrotic effects of these agents in human valve cells.
Introduction. Recent studies revealed that differentiation of valvular interstitial cell into myofibroblasts played an important role in pathological valve remodeling in rheumatic valvular disease. Objective. To investigate effects of atorvastatin, olmesartan, and resveratrol on Transforming Growth Factor β1-induced fibrosis. Methods. Valvular interstitial cell was isolated from 12-weeks male New Zealand rabbit (Oryctolagus cuniculus). Culture cells was divided into 4 groups, control group, group I (0.5 mg/mL Atorvastatin), group II (100 nmol/L Olmesartan), group III (50 μM/L Resveratrol) and group IV (combinations). All group were exposed to 100 nM Transforming Growth Factor β1 for 24 hours. Results. Immunochemical staining demonstrated that cells were completely differentiated into myofibroblasts with mean expression of α-smooth muscle actin 24522.64±4566.994. Atorvastatin, olmesartan, resveratrol, and its combination significantly reduced α-smooth muscle actin expression (6823±1735.3, 6942.7±2455.9, 14176.2±3343.3, 5051.8±1612.2 respectively (p<0.001). Conclusion. Our data showed atorvastatin, olmesartan, resveratrol, and its combination significantly reduce Transforming Growth Factor β1-induced valvular fibrosis.
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Suwanto et al. (2022) studied Valvular fibrosis. Atorvastatin, olmesartan, resveratrol, and combinations vs. Control group (TGF-β1 only) was evaluated on α-smooth muscle actin expression (p=<0.001). Atorvastatin, olmesartan, resveratrol, and their combination significantly reduced TGF-β1-induced α-smooth muscle actin expression in rabbit valvular interstitial cells (p<0.001).
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