Key result
Local administration of epinephrine during nasal septoplasty in a healthy 28-year-old man caused severe hypertension, ventricular tachycardia, and cardiac arrest, requiring resuscitation.
Why the study?
Rapid absorption or inadvertent intravascular injection of locally used epinephrine can cause unexpected cardiovascular effects, and management of resulting arrhythmias requires careful consideration.
Case Report (n=1)
No
Highlights the risk of severe cardiovascular adverse events from topical/submucosal epinephrine and cautions against the use of beta-blockers in managing epinephrine-induced hypertension.
No takes yet. Share an insight, caveat, or question.
Local epinephrine may precipitate arrest even in healthy patients; this case leaves open questions on dosing and hypertension management.
Ren et al. (2021) conducted a case report in Cardiovascular crisis after epinephrine use (n=1). Local epinephrine was evaluated on Cardiovascular crisis (hypertension, ventricular tachycardia, cardiac arrest). Local administration of epinephrine during nasal septoplasty in a healthy 28-year-old man caused severe hypertension, ventricular tachycardia, and cardiac arrest, requiring resuscitation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: