Key result
Submucosal injection of low-dose epinephrine induced ventricular tachycardia and cardiac arrest in a 35-year-old male with undiagnosed variant angina.
Case Report (n=1)
Low-dose epinephrine injection can provoke severe coronary vasospasm leading to cardiac arrest in patients with underlying variant angina.
Supports caution with submucosal epinephrine in possible variant angina; single case leaves open screening needs.
This case report describes a 35-year old male who experienced ventricular tachycardia induced by intramucosal injection of epinephrine (1:100,000). Under general anaesthesia with desflurane inhalation, 1.5% lidocaine containing 1:100,000 epinephrine was injected into the nasal mucosa for septoplasty. ST segment elevation and QRS widening occurred after 10 minutes and progressed to pulseless ventricular tachycardia. A sinus rhythm was restored after cardiopulmonary resuscitation with electrical cardioversion. The cardiac enzymes were significantly elevated after the event. Exercise-stress testing and coronary angiography were normal. However, an injection of acetylcholine into the coronary artery provoked vasospasm in the left anterior descending and circumflex arteries. This case illustrates an unusual response to low dose epinephrine with cardiac arrest induced in a patient with undiagnosed variant angina.
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Ji Young Lee (2010) conducted a case report in Variant angina (n=1). Submucosal injection of epinephrine was evaluated on Ventricular tachycardia and cardiac arrest. Submucosal injection of low-dose epinephrine induced ventricular tachycardia and cardiac arrest in a 35-year-old male with undiagnosed variant angina.
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