October 1, 1997American Journal of Respiratory and Critical Care Medicine

Normoxic Lung Ischemia/Reperfusion Accelerates Shedding of Angiotensin Converting Enzyme from the Pulmonary Endothelium

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Population

Perfused rat lungs

Comparison

Normoxic lung ischemia/reperfusion (I/R) vs Control rat lungs

Design

Preclinical

Authors

EAElena N. Atochina‐VassermanRoswell Park Comprehensive Cancer Center VMVladimir R. MuzykantovCalifornia University of Pennsylvania AAAbu B. Al‐MehdiUniversity City Science Center

Discussion

Member takes

Implication

May mark endothelial injury in experimental lung I/R; leaves open translation to clinical ARDS or transplantation.

Structured PICO

Population

Perfused rat lungs

Intervention

Normoxic lung ischemia/reperfusion (I/R)

Comparator

Control rat lungs

Outcome

Angiotensin-converting enzyme (ACE) activity in perfusate and lung tissue homogenate, and pulmonary uptake of radiolabeled monoclonal antibody to ACEsurrogate

Normoxic lung ischemia/reperfusion accelerates shedding of ACE from the pulmonary endothelium, indicating vascular endothelial injury.

Cite This Study

Atochina‐Vasserman et al. (1997) studied this question.

synapsesocial.com/papers/6a8c1ccbbc51310b2bdecd1b https://doi.org/10.1164/ajrccm.156.4.96-12116

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Normoxic Lung Ischemia/Reperfusion Accelerates Shedding of Angiotensin Converting Enzyme from the Pulmonary Endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Normoxic Lung Ischemia/Reperfusion Accelerates Shedding of Angiotensin Converting Enzyme from the Pulmonary Endothelium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider