Key result
Patients with heart failure with mid-range ejection fraction had a significantly lower rate of the composite of cardiovascular mortality and heart failure readmission compared to those with reduced ejection fraction (p=0.012).
Why the study?
A new category of HFmrEF (LVEF 40%-49%) was defined in recent guidelines, warranting investigation into their clinical characteristics and long-term outcomes.
Observational (n=494)
No
Answers are grounded in this paper and cite their sources.
Patients with HFmrEF share ischemic etiology similarities with HFrEF but experience significantly lower rates of cardiovascular mortality and heart failure readmission compared to HFrEF.
According to recent guidelines, a new category of patients with heart failure (HF) with mid-range left ventricular ejection fraction (LVEF) (HFmrEF) (LVEF = 40%-49%) has been defined. The purpose of this study was to investigate the clinical characteristics and long-term outcomes of patients with HFmrEF. This was a single-center, retrospective, observational study in which we examined the clinical characteristics and outcomes of 494 consecutive patients with acute decompensated heart failure who were admitted to our institution between January 2014 and December 2016. Of this population, 282 (57.1%), 75 (15.2%), and 137 (48.6%) patients had heart failure with reduced ejection fraction (HFrEF), HFmrEF, and heart failure with preserved ejection fraction (HFpEF), respectively. Ischemic heart disease was the primary etiology in HFmrEF and HFrEF. At the time of discharge, β-blockers and renin-angiotensin system inhibitors were more frequently prescribed in HFmrEF than in HFpEF. The composite outcome of cardiovascular mortality and HF readmission was significantly lower in HFmrEF than in HFrEF. Further studies are needed to determine the effectiveness of the management of coronary artery disease and cardioprotective medications for HFmrEF.
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Ito et al. (2019) conducted an observational in Acute decompensated heart failure (n=494). Mid-range ejection fraction (LVEF 40-49%) vs. Reduced ejection fraction (LVEF <40%) and preserved ejection fraction (LVEF ≥50%) was evaluated on Composite of cardiovascular death and heart failure readmission (p=0.012). Patients with heart failure with mid-range ejection fraction had a significantly lower rate of the composite of cardiovascular mortality and heart failure readmission compared to those with reduced ejection fraction (p=0.012).
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