Key result
Improved HFmrEF is linked to better clinical outcomes than matched HFrEF or deteriorated HFmrEF.
Why the study?
Do clinical outcomes differ among HFmrEF patients based on their prior LVEF trajectory?
Cohort (n=168)
Do clinical outcomes differ among HFmrEF patients based on their prior LVEF trajectory?
p-value: p=<0.001
HFmrEF is a heterogeneous condition, and categorizing patients by their prior LVEF trajectory reveals distinct pathophysiological substrates and clinical outcomes.
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Trajectory classification may refine HFmrEF prognostication; leaves open whether it should guide therapy without prospective validation.
Rastogi et al. (2017) conducted a cohort in Heart failure with mid-range ejection fraction (n=168). HFmrEF subgroups based on prior LVEF vs. Matched HFrEF and HFpEF patients was evaluated on Clinical outcomes (p=<0.001). Patients with improved HFmrEF had significantly better clinical outcomes compared to matched HFrEF patients (P<0.001) and deteriorated HFmrEF patients (P<0.01).
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