Why the study?
Does anipamil prevent aortic intimal thickening in 2K-1C hypertensive rabbits?
Population
24 2K-1C hypertensive rabbits and normotensive age-matched controls
Comparison
Anipamil 40 mg orally, once daily, given… vs Daily oral placebo
Design
Preclinical
Follow-up
2.5 and 4 months
Authors
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Hypothesis-generating for BP-independent vascular protection by anipamil; prospective human trials needed before clinical consideration.
Does anipamil prevent aortic intimal thickening in 2K-1C hypertensive rabbits?
Anipamil prevents aortic intimal thickening in hypertensive rabbits through a direct antiproliferative action on medial smooth muscle cells, independent of blood pressure lowering.
Paolo Pauletto (1996) studied this question.
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