Key result
Pertussis toxin inhibited endothelium-dependent relaxations evoked by specific stimuli in porcine coronary arteries, indicating mediation by a Gi-protein.
Certain endothelium-dependent relaxations are mediated by a pertussis toxin-sensitive G-protein, which may be selectively impaired in regenerating endothelial cells, potentially predisposing to vasospasm.
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Suggests selective impairment in regenerating endothelium may predispose to vasospasm; leaves open relevance to human coronary disease.
Flavahan et al. (2008) studied this question. Pertussis toxin was evaluated on Endothelium-dependent relaxations. Pertussis toxin inhibited endothelium-dependent relaxations evoked by specific stimuli in porcine coronary arteries, indicating mediation by a Gi-protein.
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