Key result
Pathological t-tubule remodelling in heart failure involves both intracellular and extracellular mechanisms, with collagen increasing within the tubules and potentially driving fibrotic remodelling.
Highlights the role of extracellular matrix and collagen in pathological t-tubule remodelling in heart failure, expanding beyond intracellular mechanisms.
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Draft 2:* Highlights extracellular matrix accumulation as a potential therapeutic target in heart failure.
Crossman et al. (2017) conducted a review in Heart failure. Pathological t-tubule remodelling in heart failure involves both intracellular and extracellular mechanisms, with collagen increasing within the tubules and potentially driving fibrotic remodelling.