Key result
T-tubule remodelling plays a critical role in the transition from compensated hypertrophy to heart failure by impacting myocyte calcium handling function.
This review summarizes current knowledge on T-tubule structure, function, and remodeling mechanisms during the transition to heart failure, highlighting its impact on myocyte calcium handling.
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T-tubule network ensures synchronous Ca2+ release; leaves open whether architectural disruption drives progression in cardiomyopathy.
Guo et al. (2013) conducted a review in Heart failure. T-tubule remodelling plays a critical role in the transition from compensated hypertrophy to heart failure by impacting myocyte calcium handling function.
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