Key result
First-time isolated surgical aortic valve replacement after prior CABG was associated with a 30-day mortality of 4.4% and a 5-year survival rate of 88.4%.
Why the study?
What are the immediate and long-term outcomes of first-time isolated surgical aortic valve replacement in patients with prior CABG?
Cohort (n=113)
Yes
What are the immediate and long-term outcomes of first-time isolated surgical aortic valve replacement in patients with prior CABG?
Patients undergoing isolated surgical AVR after prior CABG have good immediate and late survival, suggesting that a history of prior CABG should not be considered an absolute indication for transcatheter AVR.
Favorable SAVR outcomes after prior CABG; supports individualized approach but leaves open need for randomized TAVR comparisons.
BACKGROUND: This multicenter study was undertaken to determine the immediate and long-term outcomes in patients undergoing a primary surgical aortic valve replacement (AVR) who had a previous coronary artery bypass graft surgery with patent grafts. METHODS: One hundred and thirteen consecutive patients (mean EuroSCORE II, 10.3 ± 7.7%, median 8.0%) who underwent first-time isolated AVR after coronary artery bypass grafting (CABG) were the subjects of this multicenter study. The procedure was performed through a full sternotomy in 95.7% of cases, a patent internal mammary artery graft was clamped in 76.6% of patients. The temperature of cardioplegia was ≤12 °C in 62.8% of patients and systemic temperature was <32 °C in 23.9% of patients. RESULTS: Thirty-day mortality was 4.4%. Stroke was observed in 8.0% of patients, low cardiac output syndrome in 14.1%, prolonged tracheal intubation in 20.8%, and intensive care unit stay was longer than five days in 19.5% of patients. Among patients with a patent internal mammary graft (91 patients), clamping of this graft (5.7% vs. 0%, p = 0.57) was associated with a nonsignificant trend toward increased 30-day mortality. One-, three- and five-year survival rates were 91.5%, 90.4%, and 88.4%, respectively. CONCLUSIONS: Patients undergoing isolated AVR after prior CABG have a good immediate and late survival. A history of prior CABG should not be considered an absolute indication for transcatheter AVR.
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Biancari et al. (2014) conducted a cohort in Aortic valve disease with prior coronary artery bypass grafting (n=113). First-time isolated surgical aortic valve replacement was evaluated on 30-day mortality. First-time isolated surgical aortic valve replacement after prior CABG was associated with a 30-day mortality of 4.4% and a 5-year survival rate of 88.4%.
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