Glibenclamide blocks volume-sensitive Cl−channels by dual mechanisms

View Full Paper

Ask AI

Bookmark

Population

Human epithelial Intestine 407 cells

Design

Preclinical

Authors

Discussion

May inform Cl- channel modulator design; hypothesis-generating and should not yet change practice.

Population

Human epithelial Intestine 407 cells

Intervention

Glibenclamide (extracellular and intracellular application at various pH levels)

Outcome

Volume-sensitive Cl- currents and depolarization-induced inactivationsurrogate

Glibenclamide inhibits swelling-activated Cl- channels from the extracellular side via dual mechanisms depending on its charged state.

Liu et al. (1998) studied this question.

View Full Paper

Ask AI

Bookmark