Key result
Chronic administration of L-NAME in rats progressively increased the number of modulated genes in the aortic media, with 53 genes modulated after 15 days and 147 genes after 30 days.
Chronic NOS inhibition in rats induces progressive gene expression changes in aortic media involving cell proliferation, matrix remodeling, and NO/cGMP signaling.
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Does not support clinical practice changes; leaves open whether progressive aortic gene modulation translates to human vascular remodeling.
Dupuis et al. (2004) studied Hypertension associated with remodeling of the arterial wall. L-NAME (N(omega)-nitro-L-arginine methyl ester) was evaluated on Number of modulated genes in aortic media. Chronic administration of L-NAME in rats progressively increased the number of modulated genes in the aortic media, with 53 genes modulated after 15 days and 147 genes after 30 days.
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