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December 1, 1991Journal of Clinical InvestigationOpen Access

The terminal complement proteins C5b-9 augment binding of high density lipoprotein and its apolipoproteins A-I and A-II to human endothelial cells.

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Population

Cultured human umbilical vein endothelial cells (HUVECs)

Comparison

Exposure to terminal complement protein… vs Untreated cells, or cells exposed to antibody…

Design

Preclinical

Authors

KHKaren HamiltonOldham Council PSPeter J. SimsUniversity of Rochester

Discussion

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Implication

May link complement activation to endothelial lipid handling; leaves open effects on vessel wall cholesterol homeostasis in vivo.

Structured PICO

P

Population

Cultured human umbilical vein endothelial cells (HUVECs)

I

Intervention

Exposure to terminal complement protein complexes C5b-9

C

Comparator

Untreated cells, or cells exposed to antibody only, C5b67, C5b-8, or other secretion agonists (histamine, thrombin, PMA, A23187)

O

Outcome

Specific binding of HDL and its apolipoproteins A-I and A-II to endothelial cellssurrogate

Terminal complement complex C5b-9 enhances the binding of HDL and its apolipoproteins to human endothelial cells, suggesting a mechanism by which intravascular complement activation may alter cholesterol homeostasis in the vessel wall.

Cite This Study

Hamilton et al. (1991) studied this question.

synapsesocial.com/papers/6a8c2f11f8241cb45bfb87f9 https://doi.org/10.1172/jci115504

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Apolipoprotein A-I as a Marker of Angiographically Assessed Coronary-Artery Disease1983 · 539 citations
2Identification and characterization of a high density lipoprotein-binding protein in cell membranes by ligand blotting.1987 · 214 citations
3A molecular theory of lipid—protein interactions in the plasma lipoproteins1974 · 727 citations
4Complement receptors and regulatory proteins in human atherosclerotic lesions.1989 · 112 citations
5Complement Proteins C5b-9 Induce Secretion of High Molecular Weight Multimers of Endothelial von Willebrand Factor and Translocation of Granule Membrane Protein GMP-140 to the Cell Surface1989 · 440 citations