Key result
In dogs with cardiomyopathy, dual chamber pacing from the lower left atrial lateral wall yielded higher cardiac output (2.3 L/min) than right atrial appendage (2.1 L/min) and coronary sinus ostium (2.0 L/min) at 120 ms AV delay.
Why the study?
Does atrial pacing lead location alter the hemodynamic effects of AV delay in dogs with pacing-induced cardiomyopathy?
Population
Dogs (n=7) with pacing-induced dilated cardiomyopathy (chronically paced at 220 beats/min for 3 weeks)
Comparison
Dual chamber AV pacing from different atrial… vs Comparison between the different atrial pacing…
Design
Preclinical
Authors
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May support atrial site optimization in cardiomyopathy models; leaves open translation to human AV synchrony.
Does atrial pacing lead location alter the hemodynamic effects of AV delay in dogs with pacing-induced cardiomyopathy?
Absolute Event Rate: 2.3% vs 2.1%
p-value: p=< 0.05
In a canine model of pacing-induced cardiomyopathy, left atrial lateral wall pacing improved cardiac output compared to right atrial or coronary sinus pacing at specific AV delays.
Hettrick et al. (2003) studied Dilated cardiomyopathy (n=7). Dual chamber AV pacing from lower left atrial lateral wall (LAW) vs. Pacing from right atrial appendage (RAA) and coronary sinus ostium (CSO) was evaluated on Cardiac output at an AV delay of 120 ms (p=< 0.05). In dogs with cardiomyopathy, dual chamber pacing from the lower left atrial lateral wall yielded higher cardiac output (2.3 L/min) than right atrial appendage (2.1 L/min) and coronary sinus ostium (2.0 L/min) at 120 ms AV delay.
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