Key result
Deep RNA sequencing of a brain biopsy successfully identified human coronavirus OC43 as the cause of fatal encephalitis in an 11-month-old boy with severe combined immunodeficiency after conventional PCR testing was negative.
Population
11-month-old boy with severe combined immunodeficiency (SCID) and symptoms of viral encephalitis
Comparison
Deep RNA sequencing of a brain biopsy sample vs Conventional diagnostic polymerase-chain-reaction…
Design
Case_report
Authors
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Deep sequencing of brain biopsy material successfully identified human coronavirus OC43 as the cause of fatal encephalitis in an immunocompromised infant after conventional PCR failed.
Case Report (n=1)
No
Deep sequencing of brain biopsy material successfully identified human coronavirus OC43 as the cause of fatal encephalitis in an immunocompromised infant after conventional PCR failed.
Morfopoulou et al. (2016) conducted a case report in Fatal viral encephalitis (n=1). Deep RNA sequencing vs. Conventional diagnostic PCR assay was evaluated on Pathogen identification. Deep RNA sequencing of a brain biopsy successfully identified human coronavirus OC43 as the cause of fatal encephalitis in an 11-month-old boy with severe combined immunodeficiency after conventional PCR testing was negative.
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