Key result
Neonates with respiratory distress had significantly higher serum cardiac troponin T levels compared to healthy controls (0.041 vs 0.022 ng/ml; p=0.001).
Why the study?
Are cardiac troponin T levels elevated in neonates with respiratory distress compared to healthy infants?
Case-Control (n=100)
Are cardiac troponin T levels elevated in neonates with respiratory distress compared to healthy infants?
Absolute Event Rate: 0.041% vs 0.022%
p-value: p=0.001
Cardiac troponin T is elevated in neonates with respiratory distress, particularly those requiring inotropic support, suggesting it may serve as a useful marker for myocardial dysfunction in this population.
May indicate myocardial dysfunction in neonatal respiratory distress; leaves open clinical utility pending prospective validation.
The purpose of this study is to assess cardiac troponin T(cTnT) in neonates with respiratory distress as a marker of myocardial dysfunction. Eighty neonates with respiratory distress and 20 healthy infants were included in the study. Patients were subdivided into 4 groups according to the etiology. Serum cardiac troponin T was measured using ELISA technique. Cardiac troponin T levels were significantly higher (p = 0.001) in neonates with respiratory distress (0.041 ± 0.02 ng/ml) compared with controls(0.022 ± 0.012). Infants with respiratory distress syndrome had the highest cTnT levels (0.043 ± 0.022 ng/ml), while those with transient tachypnea had the lowest levels (0.036 ± 0.017 ng/ml). Also, cTnT levels were significantly higher in neonates who required inotropic support when compared to those without inotropes. We did not find statistically significant differences between survivors and non-survivors. Cardiac troponin T is higher in neonates with respiratory distress compared to healthy infants. It could be used as a useful marker for myocardial dysfunction.
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Fahmey et al. (2018) conducted a case-control in Respiratory distress (n=100). Respiratory distress vs. Healthy infants was evaluated on Serum cardiac troponin T levels (p=0.001). Neonates with respiratory distress had significantly higher serum cardiac troponin T levels compared to healthy controls (0.041 vs 0.022 ng/ml; p=0.001).
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