Key result
Increasing myoplasmic ADP from <0.1 microm to 40 microm decreased the amplitude of the twitch response by 47 +/- 6% in mechanically skinned rat fast-twitch fibres.
ADP accumulation significantly reduces the amplitude and slows the time course of twitch responses in rat fast-twitch skeletal muscle fibers, suggesting a crucial role in metabolic fatigue.
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Hypothesis-generating for ADP in fast-twitch fatigue; should not yet change clinical management of human muscle or cardiac performance.
Macdonald et al. (2004) studied this question. Myoplasmic ADP vs. < 0.1 microm ADP was evaluated on Amplitude of the twitch response. Increasing myoplasmic ADP from <0.1 microm to 40 microm decreased the amplitude of the twitch response by 47 +/- 6% in mechanically skinned rat fast-twitch fibres.
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