Population
Mechanically skinned skeletal muscle fibres of the rat
Comparison
Different concentrations of ADP vs Lower concentrations of ADP
Design
Preclinical
Authors
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May modulate skeletal muscle SR Ca2+ handling in animals; hypothesis-generating for cardiac energetics and requires validation before clinical consideration.
ADP acts as an important modulator of sarcoplasmic reticulum function in skeletal muscle by decreasing the Ca2+ pump rate and increasing Ca2+ leak, thereby reducing Ca2+ loading ability.
Macdonald et al. (2001) studied this question.
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