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Metabolites from the Plakortis genus of sponges are reviewed, with major focus on P. halichondrioides, P.simplex, P. angulospiculatus, P. lita, P. nigra, P. quasiamphiaster, P. zygompha, and the closely related Plakinastrella onkodes. The structures, stereochemistry, pharmacological activity and selected syntheses of these metabolites are discussed. Peroxy containing, polyketide derived metabolites constitute a prevalent class of biologically potent metabolites from Plakortis species.
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Kitching et al. (2004) studied this question.
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