Population
Human umbilical vein endothelial cells (HUVECs)
Comparison
Angiopoietin-1 exposure and Egr-1 knockdown… vs Control HUVECs without Egr-1 knockdown
Design
Preclinical
Authors
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Egr-1 may mediate Ang-1 angiogenic signaling in endothelium; leaves open whether targeting it alters vascular outcomes in vivo.
Egr-1 is a critical transcription factor mediating Ang-1-induced endothelial cell migration, proliferation, and angiogenesis.
Abdel-Malak et al. (2008) studied this question.
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