Why the study?
Does the nitric oxide donor SNAP inhibit sarcoplasmic reticulum calcium release in porcine tracheal smooth muscle cells?
Population
Freshly dissociated porcine tracheal smooth muscle (TSM) cells
Comparison
S-nitroso-N-acetylpenicillamine vs Degraded SNAP
Design
Preclinical
Authors
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Does not support clinical use in airway disease; hypothesis-generating for NO donor effects on SR Ca2+ release in smooth muscle.
Does the nitric oxide donor SNAP inhibit sarcoplasmic reticulum calcium release in porcine tracheal smooth muscle cells?
Nitric oxide donors inhibit sarcoplasmic reticulum calcium release through both IP3 and ryanodine receptors in porcine tracheal smooth muscle cells.
Kannan et al. (1997) studied this question.
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