January 1, 2000The Journal of PhysiologyOpen Access

Action of a NO donor on the excitation–contraction pathway activated by noradrenaline in rat superior mesenteric artery

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Population

Rat superior mesenteric artery

Comparison

NO donor SNAP vs Control conditions

Design

Preclinical

Authors

PGPhilippe GhisdalUCB Pharma (Belgium)JGJean‐Pierre GomezInstitute of Applied Science and Intelligent Systems NMNicole MorelUCLouvain

Discussion

Member takes

Implication

Hypothesis-generating for cGMP-dependent NO effects in rodent vessels; leaves open translation to human vascular therapies.

Structured PICO

Population

Rat superior mesenteric artery

Intervention

NO donor SNAP (S-nitroso-N-acetylpenicillamine, 10 microM)

Comparator

Control conditions (unstimulated, KCl-stimulated, or without SNAP)

Outcome

Isometric tension, membrane potential (Vm), cytosolic calcium concentration ([Ca2+]cyt), and accumulation of inositol phosphatessurrogate

In rat superior mesenteric arteries, the NO donor SNAP inhibits noradrenaline-induced contraction and calcium signaling through a cGMP-dependent reduction in inositol phosphates.

Cite This Study

Ghisdal et al. (2000) studied this question.

synapsesocial.com/papers/6a81f5035639d4e07ebf65ee https://doi.org/10.1111/j.1469-7793.2000.t01-3-00083.x

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